Effects of localised tumour hyperthermia on pimonidazole (Ro 03-8799) pharmacokinetics in mice.

@article{Walton1989EffectsOL,
  title={Effects of localised tumour hyperthermia on pimonidazole (Ro 03-8799) pharmacokinetics in mice.},
  author={Michael I. Walton and N. M. Bleehen and Paul Workman},
  journal={British Journal of Cancer},
  year={1989},
  volume={59},
  pages={667 - 673}
}
We have investigated the effects of localised tumour hyperthermia (LTH; 43.5 degrees C x 30 min) on the acute toxicity and pharmacokinetics of the hypoxic cell sensitizer pimonidazole (Ro 03-8799) in mice. There were three treatment groups: unrestrained controls, sham-treated and LTH treated mice. LTH had minimal effects on the acute toxicity (LD50/7d) of pimonidazole with no significant difference between the three treatment groups. Pharmacokinetic studies were carried out at the maximum… CONTINUE READING