Effects of local simvastatin-alendronate conjugate in preventing periodontitis bone loss.

  title={Effects of local simvastatin-alendronate conjugate in preventing periodontitis bone loss.},
  author={Usa Price and H-O T Le and Sarah E Powell and Marian J Schmid and David B. Marx and Yijia Zhang and Dong Wei Wang and Nagamani Narayana and Richard A. Reinhardt},
  journal={Journal of periodontal research},
  volume={48 5},
BACKGROUND AND OBJECTIVE Local host-modulation therapy is an emerging approach to prevent disease progression in sites with moderate periodontitis. The combination of simvastatin and alendronate would be an intriguing host-modulatory strategy because of the bone-anabolic properties of simvastatin and the antiresorptive/bone-targeting characteristics of alendronate. The objective of this study was to evaluate the effects of local administration of a simvastatin-alendronate-β-cyclodextrin (SIM… CONTINUE READING


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