Effects of local anesthetics on monoamine oxidase, and their membrane effects.

@article{Yasuhara1982EffectsOL,
  title={Effects of local anesthetics on monoamine oxidase, and their membrane effects.},
  author={Hajime Yasuhara and Ikuho Wada and Koji Sakamoto and Kazuya Kamijo},
  journal={Japanese journal of pharmacology},
  year={1982},
  volume={32 2},
  pages={
          213-9
        }
}
The effects of various local anesthetics on rat brain and liver monoamine oxidase (MAO) and their antihemolytic and local anesthetic effects were studied. All local anesthetics tested at 1 x 10(-7) M to 1 x 10(-3) M inhibited MAO activity in rat liver mitochondria with 5-hydroxytryptamine (5-HT) as substrate. The order of potency was tetracaine>procaine>dibucaine>lidocaine>prilocaine. Tetracaine and procaine inhibited 5-HT oxidation much more than beta-phenylethylamine (PEA) oxidation… 
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