Effects of lithium on calmodulin-stimulated adenylate cyclase activity in cortical membranes from rat brain.

@article{Mrk1987EffectsOL,
  title={Effects of lithium on calmodulin-stimulated adenylate cyclase activity in cortical membranes from rat brain.},
  author={A. B. M\ork and Arne Geisler},
  journal={Pharmacology & toxicology},
  year={1987},
  volume={60 1},
  pages={17-23}
}
The influence of lithium on calmodulin-stimulated adenylate cyclase activity has been studied in vitro and after chronic treatment. Chronic lithium treatment decreased calcium-calmodulin-stimulated adenylate cyclase activity in rat cortical membranes, while no effect was observed on GTP-stimulated activity. Lithium in vitro inhibited adenylate cyclase activity stimulated by isoprenaline, GTP or calcium-calmodulin. Calcium-calmodulin-stimulated activity was more sensitive to lithium (2 mM) than… CONTINUE READING

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