Effects of lithium, alone or associated with pilocarpine, on muscarinic and dopaminergic receptors and on phosphoinositide metabolism in rat hippocampus and striatum

@article{Marinho1998EffectsOL,
  title={Effects of lithium, alone or associated with pilocarpine, on muscarinic and dopaminergic receptors and on phosphoinositide metabolism in rat hippocampus and striatum},
  author={Mar{\'i}a Manuela Marinho and Francisca Cl{\'e}a Florenço Sousa and Veralice Meireles Sales Bruin and Marcus R Vale and Glauce Socorro de Barros Viana},
  journal={Neurochemistry International},
  year={1998},
  volume={33},
  pages={299-306}
}
The mechanism of action of lithium (Li) alone or with pilocarpine (Pilo), focusing on muscarinic and dopaminergic systems and also on phosphoinositide metabolism was studied. Li (3 mEq/kg) administered to rats once (1 d) or daily for 7 days (7 d), 24 h before Pilo (15 mg/kg), exacerbated cholinergic signs, leading to tremors. convulsions and brain lesions. Increases in muscarinic receptors (MR) of 29 and 49% were observed in the hippocampus after atropine (Atro) and Li-Atro-Pilo treatments… CONTINUE READING

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