Effects of lisdexamfetamine in a rat model of binge-eating.

  title={Effects of lisdexamfetamine in a rat model of binge-eating.},
  author={Steven P. Vickers and David Hackett and Fraser Murray and Peter H. Hutson and David J. Heal},
  journal={Journal of psychopharmacology},
  volume={29 12},
Binge-eating disorder is a common psychiatric disorder affecting ~2% of adults. Binge-eating was initiated in freely-fed, lean, adult, female rats by giving unpredictable, intermittent access to ground, milk chocolate over four weeks. The rats avidly consumed chocolate during 2 hr binge sessions, with compensatory reductions of normal chow intake in these sessions and the days thereafter. Bodyweights of binge-eating rats were normal. The model's predictive validity was explored using nalmefene… CONTINUE READING
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