Effects of liraglutide in the treatment of obesity: a randomised, double-blind, placebo-controlled study.

@article{Astrup2009EffectsOL,
  title={Effects of liraglutide in the treatment of obesity: a randomised, double-blind, placebo-controlled study.},
  author={Arne Astrup and Stephan R{\"o}ssner and Luc Van Gaal and Aila M. Rissanen and Leo Niskanen and Mazin Al Hakim and Jesper Majbom Madsen and Mads Frederik Rasmussen and Michael E. J. Lean},
  journal={Lancet},
  year={2009},
  volume={374 9701},
  pages={1606-16}
}
BACKGROUND The frequency of obesity has risen dramatically in recent years but only few safe and effective drugs are currently available. We assessed the effect of liraglutide on bodyweight and tolerability in obese individuals without type 2 diabetes. METHODS We did a double-blind, placebo-controlled 20-week trial, with open-label orlistat comparator in 19 sites in Europe. 564 individuals (18-65 years of age, body-mass index 30-40 kg/m2) were randomly assigned, with a telephone or web-based… CONTINUE READING
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