Effects of liquid and freeze-dried grapefruit juice on the pharmacokinetics of praziquantel and its metabolite 4'-hydroxy praziquantel in beagle dogs.

@article{Giorgi2003EffectsOL,
  title={Effects of liquid and freeze-dried grapefruit juice on the pharmacokinetics of praziquantel and its metabolite 4'-hydroxy praziquantel in beagle dogs.},
  author={M. Giorgi and V. Meucci and E. Vaccaro and G. Mengozzi and M. Giusiani and G. Soldani},
  journal={Pharmacological research},
  year={2003},
  volume={47 1},
  pages={
          87-92
        }
}
  • M. Giorgi, V. Meucci, +3 authors G. Soldani
  • Published 2003
  • Chemistry, Medicine
  • Pharmacological research
  • Grapefruit juice changes the pharmacokinetic parameters of a variety of drugs metabolized primarily by cytochrome P450 3A. In a three-phase crossover study, six male beagle dogs were administered 100 ml of water (control), 100 ml of commercial liquid grapefruit juice, or 10 g of freeze-dried grapefruit juice (equivalent to 100 ml of liquid grapefruit juice) with 100 ml of water, followed after 2 h by single oral dose of praziquantel (30 mg kg(-1)). After treatment, the dogs were sampled at… CONTINUE READING
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