Effects of lipoprotein lipase and statins on cholesterol uptake into heart and skeletal muscle.

@article{Yokoyama2007EffectsOL,
  title={Effects of lipoprotein lipase and statins on cholesterol uptake into heart and skeletal muscle.},
  author={Masayoshi Yokoyama and Toru Seo and Taesik Park and Hiroaki Yagyu and Yunying Hu and Ni Huiping Son and Ayanna S Augustus and Reeba Kannimel Vikramadithyan and Rahul Ramakrishnan and Leslie K. Pulawa and Robert H Eckel and Ira J Goldberg},
  journal={Journal of lipid research},
  year={2007},
  volume={48 3},
  pages={646-55}
}
Regulation of cholesterol metabolism in cultured cells and in the liver is dependent on actions of the LDL receptor. However, nonhepatic tissues have multiple pathways of cholesterol uptake. One possible pathway is mediated by LPL, an enzyme that primarily hydrolyzes plasma triglyceride into fatty acids. In this study, LDL uptake and tissue cholesterol levels in heart and skeletal muscle of wild-type and transgenic mice with alterations in LPL expression were assessed. Overexpression of a… CONTINUE READING

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