Effects of lipopolysaccharide on TNF-alpha production, hepatic NOS2 activity, and hepatic toxicity in rats with cirrhosis.

@article{Heller2000EffectsOL,
  title={Effects of lipopolysaccharide on TNF-alpha production, hepatic NOS2 activity, and hepatic toxicity in rats with cirrhosis.},
  author={Joerg Heller and Philippe Sogni and Eric Barri{\`e}re and Khalid A Tazi and Laurence Chauvelot-Moachon and M C Guimont and Phuong Nhi Bories and Odile Poirel and Richard Moreau and Didier Lebrec},
  journal={Journal of hepatology},
  year={2000},
  volume={33 3},
  pages={376-81}
}
BACKGROUND/AIMS Septic shock results in high mortality in patients with cirrhosis. Nitric oxide synthase 2 (NOS2) is induced by bacterial lipopolysaccharides (LPS) and plays a major role in the inflammatory response to bacterial infections. Little is known about the regulation of NOS2 in cirrhosis under septic conditions. Thus, the aim of this study was to determine tissue NOS2 activity, serum nitrate and tumor necrosis factor (TNF-alpha) levels and hepatic toxicity in cirrhotic rats after LPS… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 22 extracted citations

Similar Papers

Loading similar papers…