Effects of lipopolysaccharide and interleukin-6 on cataleptic immobility and locomotor activity in mice

  title={Effects of lipopolysaccharide and interleukin-6 on cataleptic immobility and locomotor activity in mice},
  author={Daria Bazovkina and Marina A. Tibeikina and Alexander V. Kulikov and Nina K. Popova},
  journal={Neuroscience Letters},

ereditary catalepsy in mice is associated with the brain dysmorphology and ltered stress response

The study indicated an association between the hereditary catalepsy, neuroanatomical characteristics, and neurochemical responses to emotional stress, and the association of hereditary catAlepsy with the inherited brain dysfunction of a neurodegenerative nature is supported.

An Endocannabinoid Uptake Inhibitor from Black Pepper Exerts Pronounced Anti-Inflammatory Effects in Mice.

Intriguingly, guineensine and LPS independently induced catalepsy, but in combination this effect was abolished, and the described potent pharmacological effects might relate to the reported anti-inflammatory effects of pepper.

Role of the Distal Fragment of Chromosome 13 in the Regulation of IL-6-Induced Effect on the Behavior of Mice

The results indicate that the distal fragment of chromosome 13 is involved in the effect of IL-6 on the locomotor activity of mice, andIL-6 in both doses significantly increased the time of cataleptic freezing.

A Panax quinquefolius-Based Preparation Prevents the Impact of 5-FU on Activity/Exploration Behaviors and Not on Cognitive Functions Mitigating Gut Microbiota and Inflammation in Mice

Qiseng® prevents the symptoms of fatigue, reduced chemotherapy-induced neuroinflammation and altered neurogenesis, while regulating the mouse gut microbiota composition, thus protecting against intestinal and systemic inflammation.

Distribution of Il6st mRNA and gp130 glycoprotein in various brain structures of mice that differ in intensity of exaggerated freezing reaction (catalepsy)

The aim of the present work was to investigate the levels of Il6st mRNA, as well as the distribution of the gp130 protein and the degree of its glycosylation, in five brain regions of mice of the non-cataleptic AKR/J line and the cataleptic lines CBA/LacJ and congenic line AKR.

Expression of genes in the 111.35–116.16 million bp fragment of chromosome 13 in brain of mice with different predisposition to hereditary catalepsy

The coexpression of a large amount of genes in these brain structures in sick animals indicates the existence of a complex gene network that regulates hereditary catalepsy.



The Mapping of the Gene of Susceptibility to Catalepsy in Mice Using Polymorphic Microsatellite Markers

Using quantitative trait loci (QTL) analysis, it was shown that the haloperidol catalepsy is linked to the gene coding for D 2 receptor, and stable cataleptic immobility was developed as soon as after five or six pinches in 54% of male and female inbred CBA/Icg mice.

[Interleukin-1beta and depressive states].

Administration of Interleukin-1 beta (IL-1 beta) in pyrogenic and subpyrogenic doses induced a depression of social and exploratory behaviour in rats. A reduction in locomotor activity only occurred