Effects of lipids on bioavailability of sulfisoxazole acetyl, dicumarol, and griseofulvin in rats.

@article{Bloedow1976EffectsOL,
  title={Effects of lipids on bioavailability of sulfisoxazole acetyl, dicumarol, and griseofulvin in rats.},
  author={Duane C. Bloedow and W. Hayton},
  journal={Journal of pharmaceutical sciences},
  year={1976},
  volume={65 3},
  pages={328-34}
}
The effects of hexadecane, oleyl alcohol, polysorbate 80, trioctanoin, and triolein on the bioavailability of sulfisoxazole N1-acetyl, dicumarol, and griseofulvin were investigated. Compared to administration of the drugs in water, the rate of absorption of the drugs was either decreased or not changed by the lipids. The extent of absorption of sulfisoxazole acetyl and dicumarol was significantly increased by polysorbate 80 and triolein and not affected by hexadecane or oleyl alcohol… CONTINUE READING

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