Effects of linoleate-enriched and oleate-enriched diets in combination with alpha-tocopherol on the susceptibility of LDL and LDL subfractions to oxidative modification in humans.

@article{Reaven1994EffectsOL,
  title={Effects of linoleate-enriched and oleate-enriched diets in combination with alpha-tocopherol on the susceptibility of LDL and LDL subfractions to oxidative modification in humans.},
  author={Peter D. Reaven and B J Grasse and Diane L. Tribble},
  journal={Arteriosclerosis and thrombosis : a journal of vascular biology},
  year={1994},
  volume={14 4},
  pages={
          557-66
        }
}
This report describes the effects of feeding linoleate- or oleate-enriched diets to subjects who were concurrently taking 1200 mg/d of alpha-tocopherol on the susceptibility of low-density lipoprotein (LDL) and buoyant and dense LDL subfractions to oxidation. LDL isolated from subjects who consumed linoleate-enriched diets was more susceptible to copper-mediated oxidation, as measured by formation of conjugated dienes and lipid peroxides and loss of unsaturated fatty acids, compared with LDL… Expand
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It is demonstrated that alterations in dietary fatty acid composition can effectively alter the fatty acid distribution of LDL and HDL in hypercholesterolemic subjects and that susceptibility to LDL oxidation is altered by these changes. Expand
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TLDR
Low-density lipoprotein oxidation was measured in vitro to determine intraindividual variability and to relate oxidation to linoleic acid enrichment and was not significantly altered by the linoleate-rich diet. Expand
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It is concluded that the susceptibility of LDL to oxidation is determined not only by its antioxidant content, but also by other compositional factors, and more specifically by the ratio of oleic acid content to linoleic Acid content. Expand
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The more dense LDL subfractions, that is, LDL2 and LDL3, are more susceptible to oxidative modification and therefore may contribute more to foam cell formation than the less dense LDLSubfraction LDL1. Expand
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