Effects of lignocaine and quinidine on the persistent sodium current in rat ventricular myocytes.

@article{Ju1992EffectsOL,
  title={Effects of lignocaine and quinidine on the persistent sodium current in rat ventricular myocytes.},
  author={Yue-kun Ju and David A. Saint and Peter W. Gage},
  journal={British journal of pharmacology},
  year={1992},
  volume={107 2},
  pages={311-6}
}
1. The effects of the Class 1 antiarrhythmic agents lignocaine and quinidine on action potentials, and on sodium currents and potassium currents activated by depolarization, were examined in rat isolated ventricular myocytes by the whole cell, tight seal recording technique. 2. Tetrodotoxin and lignocaine shortened, whereas quinidine prolonged, the duration of the plateau phase of action potentials. 3. At low concentrations, lignocaine and quinidine blocked a persistent sodium current that was… CONTINUE READING

From This Paper

Topics from this paper.

Citations

Publications citing this paper.
Showing 1-10 of 17 extracted citations

Similar Papers

Loading similar papers…