Effects of light smoking consumption on the clinical course of Crohn's disease

@article{Seksik2009EffectsOL,
  title={Effects of light smoking consumption on the clinical course of Crohn's disease},
  author={Philippe Seksik and Isabelle Nion‐Larmurier and Harry Sokol and Laurent Beaugerie and Jacques Cosnes},
  journal={Inflammatory Bowel Diseases},
  year={2009},
  volume={15},
  pages={734–741}
}
Background: Cigarette smoking is associated with a more severe Crohn's disease (CD) course. However, the effect of light consumption is not known. Our aim was to characterize the effect of a light tobacco consumption on the course of CD. Methods: We analyzed the course of CD during the period 1995–2007 from data collected in 2795 consecutive patients in whom smoking habits were recorded. Patients were classified as nonsmokers (n = 1420), light smokers (1–10 cigarettes/day; n = 385), heavy… 

Figures and Tables from this paper

Impact of Smoking Cessation on the Clinical Course of Crohn’s Disease Under Current Therapeutic Algorithms: A Multicenter Prospective Study
TLDR
Continuing smokers have more disease relapses, and patients who quit smoking have a similar relapse incidence compared with nonsmokers, as evaluated in a multicenter prospective cohort study.
Effect of smoking in patients with Crohn's disease
TLDR
Significant differences in the development of fistulas and having bowel surgery in smokers compared with patients who stopped smoking are found and programmes supporting patien...
Smoking and Diet: Impact on Disease Course?
TLDR
Patients with IBD should not smoke and avoid passive smoking, and patients with UC should not be discouraged to quit, because the beneficial effect of smoking for their disease is counterbalanced by the deleterious systemic effects of tobacco.
Smoking Status at Diagnosis and Subsequent Smoking Cessation: Associations With Corticosteroid Use and Intestinal Resection in Crohn's Disease
TLDR
Smokers at CD diagnosis have higher CS‐use, CS dependency and higher risk of intestinal surgery, and quitting smoking appears to have beneficial effects on disease related outcomes, including reducing CS dependency highlighting the importance of offering early smoking cessation support.
Management of Crohn's disease in smokers: is an alternative approach necessary?
TLDR
The available evidence of the deleterious effects of smoking on CD is reviewed in detail, and alternative therapeutic approaches to CD in smokers are proposed.
Impact of smoking cigarette on the mRNA expression of cytokines in mucosa of inflammatory bowel disease.
TLDR
Smoking has a positive influence on cessation and the clinical course of UC due to the stimulation of anti-inflammatory cytokine IL 10 in mucosa, which could be associated with a worsening of the disease and response to therapy.
Is Current Smoking Still an Important Environmental Factor in Inflammatory Bowel Diseases? Results from a Population-based Incident Cohort
TLDR
Current smoking was associated with the risk of IBD and was linked to gender and age at diagnosis and was most prominent in young adults, with a difference already being seen in 18- to 19-year-olds.
Smoking, Physical Activity, Nutrition and Lifestyle: Environmental Factors and Their Impact on IBD
TLDR
Adhering to four simple lifestyle factors – never smoking, physical activity, prudent diet and body mass index <25 – may have a strong impact both on the prevention of major chronic diseases and on the course of IBD.
Impact of environmental and dietary factors on the course of inflammatory bowel disease.
TLDR
The impact of smoking on the susceptibility to develop CD and UC is firmly established, its influence on the clinical course of both diseases is still debatable, and lessons should be drawn from the investigation of the primary therapeutic effect of enteral nutrition in CD.
Perianal disease, small bowel disease, smoking, prior steroid or early azathioprine/biological therapy are predictors of disease behavior change in patients with Crohn's disease.
TLDR
The data suggest that perianal disease, small bowel disease, smoking, prior steroid use, early AZA or AZA/biological therapy are all predictors of disease behavior change in CD patients.
...
...

References

SHOWING 1-10 OF 32 REFERENCES
Effects of cigarette smoking on the long-term course of Crohn's disease.
TLDR
Patients who smoke, particularly women and heavy smokers, run a high risk of developing severe disease and immunosuppressive therapy neutralizes the influence of smoking on surgical rates.
Effect of cigarette smoking on the course of Crohn's disease.
TLDR
Data suggest that the course of Crohn's disease is less favourable in smokers than in non-smokers, as measured by the risk of surgery.
Smoking cessation and the course of Crohn's disease: an intervention study.
TLDR
Patients with Crohn's disease who stop smoking for more than 1 year have a more benign disease course than if they had never smoked.
Does Cigarette Smoking Influence the Phenotype of Crohn's Disease? Analysis Using the Montreal Classification
TLDR
Smoking habit wasassociated with age at diagnosis and disease location in Crohn's disease, while disease location was associated with the rate of development of stricturing complications and requirement for surgery.
Smoking in Crohn's disease: effect on localisation and clinical course.
TLDR
The course of Crohn's disease analysed in different ways was unfavourable for smokers, especially heavy smokers, and patients with Crohn't disease should be dissuaded from smoking.
Effect of cigarette smoking on recurrence of Crohn's disease.
Cigarette smoking and risk of clinical relapse in patients with Crohn's disease.
Active and Passive Smoking in Childhood Is Related to the Development of Inflammatory Bowel Disease
TLDR
Smoking by age 10 was associated with an earlier age at diagnosis with UC, but not with CD, suggesting that becoming a regular smoker at a younger age may be associated with a subsequent diagnosis of IBD.
Cigarette smoking and quality of life in patients with inflammatory bowel disease
TLDR
There is a relationship between smoking and disease-specific quality of life in both ulcerative colitis and Crohn's disease and the hypothesis is presented that a part of the observed differences in the studiedquality of life dimensions with respect to age, sex and disease group are related to concomitant oral contraceptive use.
...
...