Effects of ligands with different water solubilities on self-assembly and properties of targeted nanoparticles.

@article{Valencia2011EffectsOL,
  title={Effects of ligands with different water solubilities on self-assembly and properties of targeted nanoparticles.},
  author={Pedro M. Valencia and Mikhail H Hanewich-Hollatz and Weiwei Gao and Fawziya Karim and R{\'o}bert Langer and Rohit Karnik and Omid C Farokhzad},
  journal={Biomaterials},
  year={2011},
  volume={32 26},
  pages={6226-33}
}
The engineering of drug-encapsulated targeted nanoparticles (NPs) has the potential to revolutionize drug therapy. A major challenge for the smooth translation of targeted NPs to the clinic has been developing methods for the prediction and optimization of the NP surface composition, especially when targeting ligands (TL) of different chemical properties are involved in the NP self-assembly process. Here we investigated the self-assembly and properties of two different targeted NPs decorated… CONTINUE READING
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