Effects of lidocaine administration on hemodynamics and cytokine responses to endotoxemia in rabbits.

@article{Taniguchi2000EffectsOL,
  title={Effects of lidocaine administration on hemodynamics and cytokine responses to endotoxemia in rabbits.},
  author={Takumi Taniguchi and Kazuhiko Shibata and Ken Yamamoto and Yuzo Mizukoshi and Tsutomu Kobayashi},
  journal={Critical care medicine},
  year={2000},
  volume={28 3},
  pages={755-9}
}
OBJECTIVE To investigate the effects of lidocaine administration on hemodynamics and cytokine concentrations in Escherichia coli endotoxemia in rabbits. DESIGN Randomized, prospective laboratory study. SETTING University laboratory. SUBJECTS Thirty-two Japanese rabbits anesthetized with urethane and ventilated mechanically. INTERVENTIONS Animals were randomly assigned to one of four groups: endotoxemic controls (n = 8), receiving intravenous E. coli endotoxin (0.5 mg/kg bolus) via the… CONTINUE READING