Effects of levodropropizine on vagal afferent C‐fibres in the cat

@article{Shams1996EffectsOL,
  title={Effects of levodropropizine on vagal afferent C‐fibres in the cat},
  author={Hashim Shams and Luisa Daffonchio and Peter Scheid},
  journal={British Journal of Pharmacology},
  year={1996},
  volume={117}
}
1 Levodropropizine (LVDP) is an effective antitussive drug. Its effects on single‐unit discharge of vagal afferent C‐fibres were tested in anaesthetized cats to assess whether an inhibition of vagal C‐fibres is involved in its antitussive properties. Vagal C‐fibres, identified by their response to phenylbiguanide (PBG), were recorded via suction electrodes from the distal part of the cut vagus. Based on their response to lung inflation, C‐fibres were classified as pulmonary (19 fibres) or non… 
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References

SHOWING 1-10 OF 26 REFERENCES
Lung C‐fibre receptor activation and defensive reflexes in anaesthetized cats.
TLDR
It is concluded that the pulmonary C‐fibre reflex powerfully inhibits airway defensive reflexes, and that its activation is unlikely to contribute positively to coughing induced by aerosols of capsaicin and similar agents.
Effects of thromboxane on respiration and pulmonary circulation in the cat: role of vagus nerve.
TLDR
The data suggest that the effects of TxA2 and of its mimetic U-46619 on respiration are mediated by the stimulation of vagal afferent fibers, whereas pulmonary hypertension is unrelated to vagal activity.
Capsaicin-induced desensitization of airway mucosa to cigarette smoke, mechanical and chemical irritants
TLDR
It is reported here that cigarette smoke as well as light mechanical or local chemical irritation and vagal nerve stimulation induced a subepithelial oedema in the rat trachea and bronchial tree, as indicated by extravasation of Evans blue.
Antitussive properties of levodropropizine.
TLDR
After oral administration to the guinea-pig the antitussive activity of levodropropizine was comparable with those of both droPropizine and codeine against coughing induced by irritant aerosols.
General pharmacology of the new antitussive levodropropizine.
TLDR
Levodropropizine appears to have a better tolerability index than the racemate, and has affinity for H1-histaminic and alpha-adrenergic receptors.
...
1
2
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