Effects of levodopa on striatal monoamines in mice with levodopa-induced hyperactivity.

@article{Nicholas2008EffectsOL,
  title={Effects of levodopa on striatal monoamines in mice with levodopa-induced hyperactivity.},
  author={Anthony P. Nicholas and Kerstin Buck and Boris Ferger},
  journal={Neuroscience letters},
  year={2008},
  volume={443 3},
  pages={204-8}
}
The present study examines striatal monoamine changes in a murine model of levodopa-induced dyskinesia (LID), a common side effect of Parkinson's disease (PD) therapy. Mice previously exposed to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) and later made hyperactive with high-dose (200mg/kg, i.p.) exogenous levodopa were compared to mice with normal motor behavior who received either levodopa without previous MPTP or no treatment at all. Using high-performance liquid chromatography… CONTINUE READING