Effects of levodopa on endocannabinoid levels in rat basal ganglia: implications for the treatment of levodopa-induced dyskinesias.

@article{Ferrer2003EffectsOL,
  title={Effects of levodopa on endocannabinoid levels in rat basal ganglia: implications for the treatment of levodopa-induced dyskinesias.},
  author={Bel{\'e}n Ferrer and Nick Asbrock and Satish Kathuria and Daniele Piomelli and Andrea Giuffrida},
  journal={The European journal of neuroscience},
  year={2003},
  volume={18 6},
  pages={1607-14}
}
The majority of Parkinson's disease patients undergoing levodopa therapy develop disabling motor complications (dyskinesias) within 10 years of treatment. Stimulation of cannabinoid receptors, the pharmacological target of Delta 9-tetrahydrocannabinol, is emerging as a promising therapy to alleviate levodopa-associated dyskinesias. However, the mechanisms underlying this beneficial action remain elusive, as do the effects exerted by levodopa therapy on the endocannabinoid system. Although… CONTINUE READING

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