Effects of levo-alpha-acetylmethadol (LAAM) on morphine self-administration in the rat

@article{Lukas1981EffectsOL,
  title={Effects of levo-alpha-acetylmethadol (LAAM) on morphine self-administration in the rat},
  author={Scott E. Lukas and J. Edward Moreton and Naim Khazan},
  journal={Psychopharmacology},
  year={1981},
  volume={73},
  pages={12-16}
}
Rats bearing cerebrocortical electrodes for recording the electroencephalogram (EEG) were rendered tolerant to and physically dependent on morphine and subsequently trained to self-administer morphine (10 mg/kg/injection) through a chronic intravenous cannula. Morphine was available for selfadministration 24 h/day. Once morphine intake had stabilized (10–12… CONTINUE READING