Effects of lead exposure on the expression of phospholipid hydroperoxidase glutathione peroxidase mRNA in the rat brain.

@article{Kang2004EffectsOL,
  title={Effects of lead exposure on the expression of phospholipid hydroperoxidase glutathione peroxidase mRNA in the rat brain.},
  author={J. Kang and D. Sul and J. K. Kang and S. Nam and H. Kim and E. Lee},
  journal={Toxicological sciences : an official journal of the Society of Toxicology},
  year={2004},
  volume={82 1},
  pages={
          228-36
        }
}
  • J. Kang, D. Sul, +3 authors E. Lee
  • Published 2004
  • Chemistry, Medicine
  • Toxicological sciences : an official journal of the Society of Toxicology
Oxidative damage associated with lead in the brain has been proposed as a possible mechanism of lead toxicity. Of the many antioxidant enzymes, phospholipid hydroperoxidase glutathione peroxidase (PHGPx) is known to protect cells from lipid peroxide-mediated damage by catalyzing lipid peroxide reduction. In this study, the effects of lead on the activity and expression of PHGPx mRNA were investigated in the brains of rats exposed to lead for 8 weeks. Male Sprague-Dawley rats (3 week old, n = 40… Expand
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