Effects of lead exposure on bromocriptine-induced penile erection in rats.


In the present work we have studied the effects of lead exposure on penile erection induced by bromocriptine. Intraperitoneal injection of bromocriptine (2, 3, 4 and 8 mg/kg) induced dose-related penile erection in rats. Maximum response was observed with 4 mg/kg of the drug. Lead exposure (as Pb-acetate in drinking water) for periods of 7, 14, 21 and 28 days decreased the bromocriptine-induced penile erection response. Higher concentrations of lead (0.05%) were shown to cause a more prominent decrease of penile erection. The same procedure for lead administration did not significantly alter penile erection induced by physostigmine (0.1 and 0.3 mg/kg, intraperitoneally). In a series of experiments, blood lead concentrations were measured 7 and 21 days after lead exposure. Significant increases of lead concentrations were found after lead exposure. It is concluded that lead can influence bromocriptine-induced penile erection.

Cite this paper

@article{GhaziKhansari1997EffectsOL, title={Effects of lead exposure on bromocriptine-induced penile erection in rats.}, author={Mahmoud Ghazi-Khansari and Iraj Heidari and Mohammad Reza Zarrindast}, journal={Pharmacology & toxicology}, year={1997}, volume={81 2}, pages={81-4} }