Effects of laser irradiation (670-nm InGaP and 830-nm GaAlAs) on burn of second-degree in rats


This study investigated the effects of 670-nm indium gallium phosphide (InGaP) and 830-nm gallium aluminum arsenide (GaAlAs) laser therapy on second-degree burns induced on the back of Wistar rats. Sixty-three male Wistar rats were anesthetized, and second-degree burns were made on their back. The animals were then divided randomly into three groups: control (C), animals treated with 670-nm InGaP laser (LIn), and animals treated with 830-nm GaAlAs laser (LGa). The wound areas were removed after 2, 6, 10, 14, and 18 days of treatment and submitted to structural and morphometric analysis. The following parameters were studied: total number of granulocytes and fibroblasts, number of newly formed blood vessels, and percentage of birefringent collagen fibers in the repair area. Morphometric analysis showed that different lasers 670-nm InGaP and 830-nm GaAlAs reduced the number of granulocytes and an increase of newly formed vessels in radiated lesions. The 670-nm InGaP laser therapy was more effective in increasing the number of fibroblasts. The different treatments modified the expression of VEGF and TGF-β1, when compared with lesions not irradiated. The different types of light sources showed similar effects, improved the healing of second-degree burns and can help for treating this type of injury. Despite the large number of studies with LLTI application in second-degree burns, there is still divergence about the best irradiation parameters to be used. Further studies are needed for developing a protocol effective in treating this type of injury.

DOI: 10.1007/s10103-014-1573-9

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@article{Chiarotto2014EffectsOL, title={Effects of laser irradiation (670-nm InGaP and 830-nm GaAlAs) on burn of second-degree in rats}, author={Gabriela Bortolança Chiarotto and Lia Mara Grosso Neves and Marcelo Augusto Marreto Esquisatto and Maria Esm{\'e}ria Corezola do Amaral and Gl{\'a}ucia Maria Tech dos Santos and Fernanda Aparecida Sampaio Mendonça}, journal={Lasers in Medical Science}, year={2014}, volume={29}, pages={1685-1693} }