Effects of lactate on the voltage-gated sodium channels of rat skeletal muscle: modulating current opinion.

@article{Rannou2012EffectsOL,
  title={Effects of lactate on the voltage-gated sodium channels of rat skeletal muscle: modulating current opinion.},
  author={Fabrice Rannou and Rapha{\"e}l Leschiera and Marie Agnes Giroux-Metges and Jean Pierre Pennec},
  journal={Journal of applied physiology},
  year={2012},
  volume={112 9},
  pages={
          1454-65
        }
}
During muscle contraction, lactate production and translocation across the membrane increase. While it has recently been shown that lactate anion acts on chloride channel, less is known regarding a potential effect on the voltage-gated sodium channel (Na(v)) of skeletal muscle. The electrophysiological properties of muscle Na(v) were studied in the absence and presence of lactate (10 mM) by using the macropatch-clamp method in dissociated fibers from rat peroneus longus (PL). Lactate in the… CONTINUE READING

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