Effects of l-tyrosine on mixed-acting sympathomimetic-induced pressor actions

@article{Hull1992EffectsOL,
  title={Effects of l-tyrosine on mixed-acting sympathomimetic-induced pressor actions},
  author={Keith M. Hull and Timothy J. Maher},
  journal={Pharmacology Biochemistry and Behavior},
  year={1992},
  volume={43},
  pages={1047-1052}
}
  • K. Hull, T. Maher
  • Published 1 December 1992
  • Biology
  • Pharmacology Biochemistry and Behavior
View on Elsevier
doi.org
13 Citations
Background Citations
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13 Citations

Citation Type

Citation Type

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The results suggest that selegiline transdermal system 6 mg/24 h does not significantly alter the pharmacodynamics or pharmacokinetics of either pseudoephedrine or phenylpropanolamine when administered to healthy volunteers; however, it is prudent to avoid coadministration of selegILine transDERmal system and sympathomimetics.
4 Aromatic Amino Acids in the Brain
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The abilities of the precursor amino acids, tryptophan and tyrosine, to control the rates at which neurons can produce and release their neurotransmitter products underlie a number of physiological processes, and also constitute a potential tool for amplifying or decreasing synaptic neurotransmission.
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TLDR
Only caffeine was thermogenic in the given dose and caused no haemodynamic side effects, and the sample size was probably too small to detect any appetite suppressant properties of the treatments.
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L-tyrosinatonickel(II) complex: synthesis and structural, spectroscopic, magnetic, and biological properties of 2{[Ni(L-Tyr)2(bpy)]}·3H2O·CH3OH.
TLDR
The complex 2{[Ni(L-Tyr)2(bpy)]}·3H2O·CH3OH [1, where L-tyr = L-tyrosine; bpy = 2,2'-bipyridine (2, 2'-bpy], obtained in crystalline form and characterized by X-ray and spectroscopic and magnetic methods, revealed the occurrence of hydrogen-bonded metal pairs.
Phenylpropanolamine) in Healthy Volunteers Selegiline Transdermal System and Two Sympathomimetic Agents (Pseudoephedrine and Evaluation of the Potential for Pharmacodynamic and Pharmacokinetic Drug Interactions Between
Additional services and information for The Journal of Clinical Pharmacology can be found at: Email Alerts: http://www.jclinpharm.org/cgi/alerts Subscriptions: http://www.jclinpharm.org/subscriptions…
Dietary herbal supplements with phenylephrine for weight loss.
TLDR
Pilot studies suggest phenylephrine is not efficacious for weight loss, although no toxicity was seen, and there were no significant safety issues in either study.
Body fat loss achieved by stimulation of thermogenesis by a combination of bioactive food ingredients: a placebo-controlled, double-blind 8-week intervention in obese subjects
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The bioactive supplement increased 4-h thermogenesis by 90 kJ more than placebo, and the effect was maintained after 8 weeks and accompanied by a slight reduction in fat mass, which may support weight maintenance after a hypocaloric diet.
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It is concluded that ephedra and ephedrine provide modest, short-term improvements in weight loss, but that they are associated with increased rates of side-effects.
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References

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  • K. Hull, T. Maher
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Results indicate that L-TYR specifically potentiates the anorectic activity of the studied mixed-acting sympathomimetics and are consistent with the requirement of the central conversion of L- TYR to catecholamines via TYR hydroxylase for this response.
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The sympathomimetic properties of PPA and its individual component enantiomers d‐ and l‐norephedrine (NOR) were examined in isolated perfused/superfused caudal arteries from Sprague‐Dawley (SD) rats to demonstrate that the norePhedrines acted as partial agonists primarily via direct stimulation of postjunctional alpha1‐adrenoceptors with relatively low potency.
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TLDR
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Tyrosine's pressor effect in hypotensive rats is not mediated by tyramine.
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TLDR
Although some of the statistically significant changes in regional brain BH4 levels are small, previous reports of the failure of biopterin to change in response to more than 30 other central nervous system drugs, including such stimulants as methylphenidate and cocaine, makes them noteworthy.
β2‐Adrenoceptor influences on the α1‐ and α2‐mediated vasoconstriction induced by phenylpropanolamine and its two component enantiomers in the pithed rat
TLDR
It is concluded that each form of the drug possesses the intrinsic ability to interact with the α1‐, α2‐ and β2‐adrenoceptors in the system used and that the interaction with those adrenoceptor determines the net increase in diastolic blood pressure that follows the intravenous administration of the compounds.
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