Effects of kinesin-5 inhibition on dendritic architecture and microtubule organization

@inproceedings{Kahn2015EffectsOK,
  title={Effects of kinesin-5 inhibition on dendritic architecture and microtubule organization},
  author={Olga I. Kahn and V. K. Sharma and Christian Gonz{\'a}lez-Billault and Peter W. Baas},
  booktitle={Molecular biology of the cell},
  year={2015}
}
Kinesin-5 is a slow homotetrameric motor protein best known for its essential role in the mitotic spindle, where it limits the rate at which faster motors can move microtubules. In neurons, experimental suppression of kinesin-5 causes the axon to grow faster by increasing the mobility of microtubules in the axonal shaft and the invasion of microtubules into the growth cone. Does kinesin-5 act differently in dendrites, given that they have a population of minus end-distal microtubules not… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 22 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 62 references

The kinesin-2 family member KIF3C regulates microtubule dynamics and is required for axon growth and regeneration.

The Journal of neuroscience : the official journal of the Society for Neuroscience • 2013
View 1 Excerpt

Microtubule redistribution in growth cones elicited by focal inactivation of kinesin-5.

The Journal of neuroscience : the official journal of the Society for Neuroscience • 2012
View 9 Excerpts

Mitotic motors coregulate microtubule patterns in axons and dendrites.

The Journal of neuroscience : the official journal of the Society for Neuroscience • 2012
View 14 Excerpts

Similar Papers

Loading similar papers…