Effects of kinase inhibitors on TGF-β induced upregulation of Kv1.3 K+ channels in brain macrophages

@article{Schilling2003EffectsOK,
  title={Effects of kinase inhibitors on TGF-β induced upregulation of Kv1.3 K+ channels in brain macrophages},
  author={Tom Schilling and Claudia Eder},
  journal={Pfl{\"u}gers Archiv},
  year={2003},
  volume={447},
  pages={312-315}
}
Deactivation of brain macrophages (microglia) by transforming growth factor-β (TGF-β) is characterized by enhanced Kv1.3 K+ channel expression. The intracellular mechanisms by which TGF-β causes K+ channel upregulation in microglia have remained unclear. We show here that the protein kinase inhibitor H7 abolishes TGF-β-induced increases in delayed rectifier K+ current density. However, this effect cannot be related to inhibition of protein kinase C (PKC) or protein kinase A (PKA) activity… CONTINUE READING

Citations

Publications citing this paper.
SHOWING 1-10 OF 12 CITATIONS

Inhibition of voltage-gated K+ channels in dendritic cells by rapamycin.

  • American journal of physiology. Cell physiology
  • 2010
VIEW 1 EXCERPT
CITES BACKGROUND

References

Publications referenced by this paper.
SHOWING 1-8 OF 8 REFERENCES

Upregulation of Kv1.3 K(+) channels in microglia deactivated by TGF-beta.

  • American journal of physiology. Cell physiology
  • 2000
VIEW 4 EXCERPTS

IGF-1 up-regulates K+ channels via PI3-kinase, PDK1 and SGK1

  • Pflügers Archiv - European Journal of Physiology
  • 2001
VIEW 1 EXCERPT