• Corpus ID: 23972045

Effects of ketoprofen and indomethacin on leukocyte migration in two models of pleurisy induced by carrageenan or zymosan-activated serum in rats.

@article{Vannier1989EffectsOK,
  title={Effects of ketoprofen and indomethacin on leukocyte migration in two models of pleurisy induced by carrageenan or zymosan-activated serum in rats.},
  author={E. Vannier and Monique Roch-Arveiller and Benoit Molinie and Bernard Terlain and J. P. Giroud},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={1989},
  volume={248 1},
  pages={
          286-91
        }
}
The effect of nonsteroidal anti-inflammatory drugs on the in vivo leukocyte migration is not understood fully. In the present study, the effects of indomethacin and ketoprofen on the intrapleural leukocyte accumulation induced by carrageenan or zymosan-activated serum (ZAS) were investigated. Rats were given indomethacin or ketoprofen p.o. (1, 3 or 9 mg/kg) 1 hr before intrapleural injection of carrageenan (1 mg) or ZAS (0.5 ml). Pleural exudates were harvested 4 hr later. In each model of… 

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