• Corpus ID: 23972045

Effects of ketoprofen and indomethacin on leukocyte migration in two models of pleurisy induced by carrageenan or zymosan-activated serum in rats.

  title={Effects of ketoprofen and indomethacin on leukocyte migration in two models of pleurisy induced by carrageenan or zymosan-activated serum in rats.},
  author={E. Vannier and Monique Roch-Arveiller and Benoit Molinie and Bernard Terlain and J. P. Giroud},
  journal={The Journal of pharmacology and experimental therapeutics},
  volume={248 1},
The effect of nonsteroidal anti-inflammatory drugs on the in vivo leukocyte migration is not understood fully. In the present study, the effects of indomethacin and ketoprofen on the intrapleural leukocyte accumulation induced by carrageenan or zymosan-activated serum (ZAS) were investigated. Rats were given indomethacin or ketoprofen p.o. (1, 3 or 9 mg/kg) 1 hr before intrapleural injection of carrageenan (1 mg) or ZAS (0.5 ml). Pleural exudates were harvested 4 hr later. In each model of… 

Effect of treatment with interleukin-1 receptor antagonist on the development of carrageenan-induced pleurisy in the rat

Pretreatment of rats with the human interleukin-1 receptor antagonist (IL-1ra) by the subcutaneous route at −0.5 h, relative to the intrapleural injection of carrageenan (CG), suppressed the

Involvement of platelet-activating factor in zymosan-induced rat pleurisy

The results suggest that in zymosan-induced rat pleurisy, histamine and/or serotonin are the main mediators of exudation at 0.5 hr and that PAF may be partly responsible for exUDation at0.5 hrs.

Critical Role of L-Selectin and Histamine H4 Receptor in Zymosan-Induced Neutrophil Recruitment from the Bone Marrow: Comparison with Carrageenan

Findings indicate that both H4 and L-selectin regulate zymosan-induced neutrophil release from bone marrow and subsequent infiltration in the pleurisy model.

Prostaglandin Receptors EP2, EP3, and IP Mediate Exudate Formation in Carrageenin-Induced Mouse Pleurisy

Participation of EP2 and EP3 along with IP in pleural exudate formation but not in leukocyte migration in carrageenin-induced mouse pleurisy is demonstrated.

Effect of norathyriol, isolated from Tripterospermum lanceolatum, on A 23 187-induced pleurisy and analgesia in mice

The inhibitory effect of norathyriol on the A 23 187-induced pleurisy and acetic acid-induced writhing response in mice is proposed to be dependent on the reduction of eicosanoids mediators formation in the inflammatory site.

Paracetamol and ibuprofen block hydrothorax absorption in mice.

Paracetamol and ibuprofen acutely hinder pleural fluid recycling by lowering the fluid absorption rate (higher remaining hydrothorax volume), while they increased total white cell counts.

Ketoprofen affects the mammary immune response in dairy cows in vivo and in vitro.

Nonsteroidal anti-inflammatory drugs are commonly administered parenterally in addition to antimicrobial mastitis therapy to increase the well-being of the diseased animal. As mastitis is usually a

Effects of two different inhibitors of the arachidonic acid metabolism on platelet sequestration in endotoxic shock

It is concluded that the dual cyclo oxygengenase and lipoxygenase inhibitor ketoprofen offered significantly more effective protection against endotoxin-induced platelet sequestration in the lungs and the liver than the cyclooxygen enzyme inhibitor aspirin.

Synthesis and study of the anti-inflammatory properties of some pyrazolo[1,5-a]pyrimidine derivatives.

4,7-Dihydro-4-ethyl-2(2-thienyl)pyrazolo[1,5-a]pyrimidin-7-one (7c) proved to be the most interesting compound of the novel synthesized series, showing powerful pharmacological activity in vivo as well as in vitro, together with very weak acute toxicity.