Corpus ID: 8489348

Effects of ketoconazole on the intestinal metabolism, transport and oral bioavailability of K02, a novel vinylsulfone peptidomimetic cysteine protease inhibitor and a P450 3A, P-glycoprotein dual substrate, in male Sprague-Dawley rats.

@article{Zhang1998EffectsOK,
  title={Effects of ketoconazole on the intestinal metabolism, transport and oral bioavailability of K02, a novel vinylsulfone peptidomimetic cysteine protease inhibitor and a P450 3A, P-glycoprotein dual substrate, in male Sprague-Dawley rats.},
  author={Yan Zhang and Yu Fung Hsieh and T Izumi and Emil T. Lin and Leslie Z. Benet},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={1998},
  volume={287 1},
  pages={
          246-52
        }
}
  • Yan Zhang, Yu Fung Hsieh, +2 authors Leslie Z. Benet
  • Published in
    The Journal of pharmacology…
    1998
  • Chemistry, Medicine
  • We investigated the effects of ketoconazole on the oral bioavailability of morpholine-urea-phenylalanine-homophenylalanine-vinylsulfone-phenyl (K02), a vinylsulfone peptidomimetic cysteine protease inhibitor, and a P450 3A (CYP3A) and P-glycoprotein dual substrate, in male Sprague-Dawley rats, so as to evaluate the roles of CYP3A and P-gp in K02 disposition. Male Sprague-Dawley rats (8-10 wk old, n = 3-6) were administered a single dose of K02 (10 mg/kg) i.v. or (30 mg/kg) p.o. with or without… CONTINUE READING

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    In vitro evaluation of the disposition of A novel cysteine protease inhibitor.

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