Effects of ketoconazole in hirsute women.

@article{Akaln1991EffectsOK,
  title={Effects of ketoconazole in hirsute women.},
  author={Sema Akalın},
  journal={Acta endocrinologica},
  year={1991},
  volume={124 1},
  pages={
          19-22
        }
}
  • S. Akalın
  • Published 1991
  • Medicine, Biology
  • Acta endocrinologica
To determine the efficacy of ketoconazole in the treatment of hirsutism, clinical and hormonal effects of this agent were evaluated with a randomized, placebo-controlled, double-blind cross-over study design. Nine hirsute women were given ketoconazole (600 mg/day) or placebo for 6 months and then crossed over. The severity of hirsutism was assessed according to the scale of Ferriman & Gallwey. Baseline serum testosterone, dehydroepiandrosterone sulphate, progesterone, estradiol, basal and… 
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After 9 months of ketoconazole treatment, the patients' Ferriman & Gallway scores improved markedly and acne had improved markedly, and Hormone patterns also became more favorable, with decreases in androgenic steroids and increases in estradiol.
Low Dose Ketoconazole is an Effective and a Relatively Safe Alternative in the Treatment of Hirsutism*
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Topically applied finasteride significantly decreased hair growth and thickness, and no adverse effects were noted in this study of women with facial hirsutism.
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Six months of topically applied finasteride (0.5%) does not affect on number and thickness of facial hirsutism significantly and despite lack of objective changes, most patients in finastride group perceived a decrease in hair growth with time.
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Because of the good absorption through the skin and good solubility of this medicine, the prepared gel formulation applied on the hirsutism area showed a significant decrease in hair growth locally, so finasteride gel is an efficient and harmless therapy in patients with idiopathic hirutism.
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There was low quality evidence for the effect of two oral contraceptive pills (OCPs) and change in androgen levels were addressed in most comparisons, change in body mass index (BMI) and improvement of other clinical signs of hyperandrogenism in one-third of studies.
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An appraisal of what is presently known about the regulation of hair growth, the various causes of excessive androgen secretion and the current methods to solve, safely, this important feminine clinical problem is provided.
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