Effects of ketamine on voltage-dependent calcium currents and membrane potentials in single bullfrog atrial cells

@article{Hatakeyama2001EffectsOK,
  title={Effects of ketamine on voltage-dependent calcium currents and membrane potentials in single bullfrog atrial cells},
  author={Noboru Hatakeyama and Mitsuaki Yamazaki and Nobuko Shibuya and Shigeo Yamamura and Yasunori Momose},
  journal={Journal of Anesthesia},
  year={2001},
  volume={15},
  pages={149-153}
}
Purpose. This study was undertaken to assess the effect of ketamine on L-type calcium channel current (ICa) and membrane action potential in the bullfrog single atrial myocyte. Methods. Bullfrog single atrial myocytes were prepared by enzymatic dispersion. Whole-cell voltage-clamp technique and current clamp technique were used to monitor ICa, membrane resting potential, and action potential. Results. Ketamine (10−5–10−3 M) showed dose-dependent inhibition of ICa in a reversible manner. The 50… CONTINUE READING