Effects of ketamine on pulmonary inflammatory responses and survival in rats exposed to polymicrobial sepsis.

@article{Yu2007EffectsOK,
  title={Effects of ketamine on pulmonary inflammatory responses and survival in rats exposed to polymicrobial sepsis.},
  author={Min Yu and Danbing Shao and Rong Yang and Xiaomei Feng and Sihai Zhu and Jian-guo Xu},
  journal={Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques},
  year={2007},
  volume={10 4},
  pages={434-42}
}
PURPOSE Ketamine is reported to suppress production of proinflammatory cytokines and activity of nuclear factor-kappa B (NF-kappaB) after lipopolysaccharide (LPS) stimulation. Our study was designed to investigate the effects of ketamine on pulmonary inflammatory responses and survival in a clinically relevant model of polymicrobial sepsis, induced by cecal ligation and puncture (CLP). METHODS After the induction of sepsis or sham-operation, animals were treated with ketamine (0.5, 5 or 10 mg… CONTINUE READING

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