Effects of ketamine on neostigmine-induced contractile and phosphatidylinositol responses of the rat trachea

@article{Saito2003EffectsOK,
  title={Effects of ketamine on neostigmine-induced contractile and phosphatidylinositol responses of the rat trachea},
  author={Masataka Saito and Osamu Shibata and Masakazu Yamaguchi and Hiroshi Miyoshi and Tetsuji Makita and Koji Sumikawa},
  journal={Journal of Anesthesia},
  year={2003},
  volume={17},
  pages={104-107}
}
Purpose. Neostigmine causes airway smooth muscle contraction through the direct stimulation of muscarinic receptors and the activation of phosphatidylinositol (PI) responses. Ketamine attenuates airway smooth muscle contraction. It is not clear whether ketamine attenuates neostigmine-induced airway smooth muscle contraction by inhibiting the PI response… CONTINUE READING