• Corpus ID: 39904405

Effects of kappa opioids on cocaine self-administration by rhesus monkeys.

@article{Negus1997EffectsOK,
  title={Effects of kappa opioids on cocaine self-administration by rhesus monkeys.},
  author={S Stevens Negus and Nancy K. Mello and Philip S. Portoghese and C E Lin},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={1997},
  volume={282 1},
  pages={
          44-55
        }
}
  • S. Negus, N. Mello, C. E. Lin
  • Published 1 July 1997
  • Biology, Psychology
  • The Journal of pharmacology and experimental therapeutics
Kappa opioid agonists attenuate some neurochemical and behavioral effects of cocaine and are being considered as potential treatments for cocaine dependence. The present study examined the effects of two kappa opioid agonists, the benzomorphan ethylketocyclazocine (EKC) and the arylacetamide U50,488, on cocaine self-administration in rhesus monkeys. Monkeys responded for 0.032 mg/kg/injection cocaine (i.v.) and 1 g banana-flavored food pellets during alternating daily sessions of cocaine and… 

Figures from this paper

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  • Biology, Psychology
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  • 2004
TLDR
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The data suggest that increased motivation for cocaine in rats with extended access may be related to increased κ opioid activity and may contribute to compulsive use.
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References

SHOWING 1-10 OF 80 REFERENCES
Role of delta opioid receptors in the reinforcing and discriminative stimulus effects of cocaine in rhesus monkeys.
TLDR
The results suggest that delta opioid receptors play, at best, a minor and inconsistent role in the reinforcing and discriminative stimulus effects of cocaine in rhesus monkeys.
Kappa opioid inhibition of morphine and cocaine self-administration in rats
Buprenorphine-induced alterations of cocaine's reinforcing effects in rhesus monkey: a dose-response analysis.
Development of behavioral sensitization to cocaine: influence of kappa opioid receptor agonists.
TLDR
It is demonstrated that the repeated activation of kappa opioid receptors prevents the locomotor activation that occurs in response to an acute cocaine challenge as well as the sensitized motor responses that develop after the repeated administration of cocaine.
Modulation of the discriminative stimulus effects of cocaine by mu and kappa opioids.
TLDR
The effects of cocaine alone and after pretreatment with selective mu and kappa opioids were determined in squirrel monkeys trained to discriminate, indicating that the observed interactions were not simply the result of additive discriminative stimulus effects.
The Effects of Nalbuphine and Butorphanol Treatment on Cocaine and Food Self-Administration by Rhesus Monkeys
TLDR
It is suggested that these opioid mixed agonist-antagonist analgesics may not be useful as pharmacotherapies for the treatment of cocaine abuse.
The effects of chronic buprenorphine treatment on cocaine and food self-administration by rhesus monkeys.
TLDR
Food self-administration was initially reduced, but tolerance to buprenorphine's suppression of food-maintained responding developed over 30 to 70 days of treatment, whereas cocaine self- Administration remained significantly suppressed.
Acute and chronic effects of flupenthixol on the discriminative stimulus and reinforcing effects of cocaine in rhesus monkeys.
TLDR
Neither acute nor chronic treatment with a low dose of flupenthixol significantly altered the discriminative stimulus or reinforcing effects of cocaine.
kappa-Opioid receptor agonists prevent sensitization to the conditioned rewarding effects of cocaine.
TLDR
It is demonstrated that sensitization develops to the conditioned rewarding effects of cocaine and that the activation of central nervous system kappa-opioid receptors prevents the development of this phenomenon.
Effects of intermittent buprenorphine administration on cocaine self-administration by rhesus monkeys.
TLDR
Investigation of the effects of 60 days of intermittent buprenorphine treatment on cocaine and food self-administration by six rhesus monkeys suggests that intermittent buPrenorphines treatment is less effective than daily bup Renorphine Treatment in reducing cocaine self-Administration by rhesUS monkeys.
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