Effects of joint loading on articular cartilage collagen metabolism: assay of procollagen prolyl 4-hydroxylase and galactosylhydroxylysyl glucosyltransferase.


The degree of joint loading on the femoral head cartilage was experimentally altered in dogs by splinting of the knee joint for 11 weeks (n = 9), and making another group (n = 6) to run on a treadmill with 15 degrees uphill inclination during a period of 15 weeks (4 km/day, 5 days a week). A third group (n = 9) served as controls. The influence of these… (More)