Effects of jarastatin, a novel snake venom disintegrin, on neutrophil migration and actin cytoskeleton dynamics.

@article{Coelho1999EffectsOJ,
  title={Effects of jarastatin, a novel snake venom disintegrin, on neutrophil migration and actin cytoskeleton dynamics.},
  author={Ana Lucia J Coelho and Marta Sampaio de Freitas and Ana L{\'u}cia Oliveira-Carvalho and Vivaldo Moura-Neto and Russolina Benedeta Zingali and Christina Barja-Fidalgo},
  journal={Experimental cell research},
  year={1999},
  volume={251 2},
  pages={379-87}
}
A new disintegrin, an RGD-containing peptide of 6 kDa called jarastatin, was purified from Bothrops jararaca venom. It is a potent inhibitor of platelet aggregation induced by ADP, collagen, and thrombin. The effect of jarastatin on neutrophil migration in vivo and in vitro and on the actin cytoskeleton dynamics of these cells was investigated. Incubation in vitro with jarastatin significantly inhibited, in a concentration-dependent manner, the chemotaxis of human neutrophils toward fMLP, IL-8… CONTINUE READING

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