Effects of itraconazole on cytochrome P-450-dependent sterol 14 alpha-demethylation and reduction of 3-ketosteroids in Cryptococcus neoformans.

@article{Bossche1993EffectsOI,
  title={Effects of itraconazole on cytochrome P-450-dependent sterol 14 alpha-demethylation and reduction of 3-ketosteroids in Cryptococcus neoformans.},
  author={Hugo F Vanden Bossche and Patrick Marichal and L Le Jeune and M. C. Coene and J Gorrens and Willy F Cools},
  journal={Antimicrobial agents and chemotherapy},
  year={1993},
  volume={37 10},
  pages={2101-5}
}
As in other pathogenic fungi, the major sterol synthesized by Cryptococcus neoformans var. neoformans is ergosterol. This yeast also shares with most pathogenic fungi a susceptibility of its cytochrome P-450-dependent ergosterol synthesis to nanomolar concentrations of itraconazole. Fifty percent inhibition of ergosterol synthesis was reached after 16 h of growth in the presence of 6.0 +/- 4.7 nM itraconazole, and complete inhibition was reached at approximately 100 nM itraconazole. This… CONTINUE READING
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