Effects of isopentyl ferulate on oxidative stress biomarkers and a possible GABAergic anxiolytic-like trait in Swiss mice.

  title={Effects of isopentyl ferulate on oxidative stress biomarkers and a possible GABAergic anxiolytic-like trait in Swiss mice.},
  author={Keylla da Conceiç{\~a}o Machado and George Laylson da Silva Oliveira and Muhammad Torequl Islam and Ant{\^o}nia Amanda Cardoso de Almeida and Ant{\^o}nio Luiz Gomes J{\'u}nior and K{\'a}tia da Conceiç{\~a}o Machado and Dami{\~a}o Pergentino de Sousa and Ana Amelia Carvalho Melo-Cavalcante and Rivelilson Mendes de Freitas},
  journal={Chemico-biological interactions},
This study aimed to evaluate the anxiolytic-like effect and the possible neuronal mechanism of action of isopentyl ferulate (IF). For this purpose, we used the marble burying test in Swiss albino mice. The biomarkers involved in oxidative stress were measured in the hippocampus homogenate of the test animals. In addition, the toxicity and antioxidant capacities were tested in Artemia salina and rat erythrocytes, respectively. The results suggest that, an acute administration of the IF at doses… Expand
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