Effects of isoflurane anesthesia and intravenous morphine self-administration on regional glucose metabolism ([18 F]FDG-PET) of male Sprague-Dawley rats.

@article{Park2017EffectsOI,
  title={Effects of isoflurane anesthesia and intravenous morphine self-administration on regional glucose metabolism ([18 F]FDG-PET) of male Sprague-Dawley rats.},
  author={Thomas Y. Park and Kevin S Nishida and Colin M. Wilson and Shalini Jaiswal and Jessica Scott and Andrew R. Hoy and Reed G. Selwyn and Bernard J. Dardzinski and Kwang H Choi},
  journal={The European journal of neuroscience},
  year={2017},
  volume={45 7},
  pages={
          922-931
        }
}
Although certain drugs of abuse are known to disrupt brain glucose metabolism (BGluM), the effects of opiates on BGluM are not well characterized. Moreover, preclinical positron emission tomography (PET) studies anesthetize animals during the scan, which limits clinical applications. We investigated the effects of (i) isoflurane anesthesia and (ii) intravenous morphine self-administration (MSA) on BGluM in rats. Jugular vein cannulated adult male Sprague-Dawley rats self-administered either… CONTINUE READING
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