Effects of isoflavones and amino acid therapies for hot flashes and co-occurring symptoms during the menopausal transition and early postmenopause: a systematic review.

@article{Thomas2014EffectsOI,
  title={Effects of isoflavones and amino acid therapies for hot flashes and co-occurring symptoms during the menopausal transition and early postmenopause: a systematic review.},
  author={Annette Joan Thomas and Rita Ismail and Lisa Jean Taylor-Swanson and Lori Cray and Janet G. Schnall and Ellen Sullivan Mitchell and Nancy Fugate Woods},
  journal={Maturitas},
  year={2014},
  volume={78 4},
  pages={
          263-76
        }
}
AIMS Review controlled clinical trials of isoflavones and amino acid preparation effects on hot flashes and at least one other symptom including mood, sleep, pain, and cognitive function that women report during the menopausal transition and early postmenopause. METHODS An experienced reference librarian searched PubMed/Medline, CINAHL Plus, PsycInfo, Cochrane Database of Systematic Reviews, Cochrane Central Register of Controlled Trials, Web of Science, EMBASE, AMED, and Alt-Health Watch for… 
Isoflavone Supplements for Menopausal Women: A Systematic Review
TLDR
It is found that isoflavones reduce hot flashes even accounting for placebo effect, attenuate lumbar spine bone mineral density (BMD) loss, show beneficial effects on systolic blood pressure during early menopause, and improve glycemic control in vitro.
Effect of Isoflavones on Hot Flushes Women Menopause: A Systematic Review
TLDR
Soy is oflavones and red clover isoflavones have a positive effect on reducing the incidence of hot flushes in postmenopausal women but a similar study is required with larger numbers of samples and corresponding measuring instruments.
Effect of soy isoflavones supplement on climacteric symptoms, bone biomarkers, and quality of life in Korean postmenopausal women: a randomized clinical trial
TLDR
This study suggests that 70 mg isoflavones supplement has beneficial effects on bone formation markers; however, it showed no benefit compared to the placebo on climacteric symptoms or quality of life.
Consensus: soy isoflavones as a first-line approach to the treatment of menopausal vasomotor complaints
TLDR
An in-depth risk assessment (EFSA 2015) concludes that the amply available human data does not indicate any suspected harmful effects from a potential interaction of isoflavones with hormone-sensitive tissues in the mammary gland, the uterus and the thyroid gland.
Soy isoflavones as a first-line approach to the treatment of menopausal vasomotor complaints February 2016
The association between an increased uptake of isoflavones and a reduced frequency of menopausal hot flushes was first described in 1992, based on a lower incidence of hot flushes in countries with a
Soy isoflavones as a first-line approach to the treatment of vasomotor symptoms of menopause
TLDR
Clinical findings indicate potential benefits of exposure to isoflavones during breast cancer treatment with tamoxifen or anastrozole and a number of data in humans do not confirm the alleged adverse effect resulting from possible interaction between is oflavones and the hormone-sensitive tissues of the mammary glands, uterus and thyroid.
Oral isoflavone supplementation on endometrial thickness: a meta-analysis of randomized placebo-controlled trials
TLDR
Oral isoflavone supplementation might have different effects in different populations and at different daily doses, and multiple-centre, larger, and long-term trials are deserved to further evaluate its effect.
Influence of a new botanical combination on quality of life in menopausal Spanish women: Results of a randomized, placebo-controlled pilot study
TLDR
Short-term intake of the botanical combination improved the Global Quality of Life of climateric women, according to the Cervantes Scale, since this is a pilot trial.
Combined Red Clover isoflavones and probiotics potently reduce menopausal vasomotor symptoms
TLDR
Results suggest that moderate doses of RCE were more effective and superior to placebo in reducing physiological and self-reported VMS, and support that objective physiological symptom assessment methods should be used together with self-report measures in future studies on menopausal VMS.
The effect of oral capsule of curcumin and vitamin E on the hot flashes and anxiety in postmenopausal women: A triple blind randomised controlled trial.
TLDR
The results of this study showed that oral intake of curcumin and vitamin E significantly reduced hot flashes in postmenopausal women but had no significant effect on anxiety, sexual function and menopausal symptoms.
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 52 REFERENCES
Extracted or synthesized soybean isoflavones reduce menopausal hot flash frequency and severity: systematic review and meta-analysis of randomized controlled trials
TLDR
Soy isoflavone supplements, derived by extraction or chemical synthesis, are significantly more effective than placebo in reducing the frequency and severity of hot flashes.
The effect of red clover isoflavones on menopausal symptoms, lipids and vaginal cytology in menopausal women: A randomized, double-blind, placebo-controlled study
TLDR
Compared with placebo, red clover isoflavone supplementation in postmenopausal women significantly decreased menopausal symptoms and had a positive effect on vaginal cytology and triglyceride levels.
Effects of mind–body therapies on symptom clusters during the menopausal transition
TLDR
A review of controlled clinical trials of mind–body therapies for hot flushes and at least one other co-occurring symptom from these groups: sleep, cognitive function, mood, and pain found no consistency in results.
Soy isoflavones and melatonin for the relief of climacteric symptoms: a multicenter, double-blind, randomized study.
TLDR
Present data do not show any advantage of isoflavones or melatonin over placebo for the relief of menopausal symptoms, whereas improvement of psychological symptoms was higher in the is oflavones+melatonin group than in the other three.
New equol supplement for relieving menopausal symptoms: Randomized, placebo-controlled trial of Japanese women
Objectives: Equol, a metabolite of the isoflavone daidzein, is hypothesized to play a major role in the health benefits of soy. We examined the effect of a new S-equol supplement on menopausal
A randomized controlled trial of the effect of dietary soy and flaxseed muffins on quality of life and hot flashes during menopause
TLDR
Neither dietary flaxseed nor soy flour significantly affected menopause-specific quality of life or hot flash symptoms in this study.
The effect of synthetic genistein on menopause symptom management in healthy postmenopausal women: a multi-center, randomized, placebo-controlled study.
TLDR
The current study provides the first evidence that a single daily dose of 30 mg of synthetic genistein reduces hot flush frequency and duration.
Effect of high-dose isoflavones on cognition, quality of life, androgens, and lipoprotein in post-menopausal women
TLDR
High-dose isoflavones is associated with improved QOL among women who have become menopausal recently, and the timing of is oflavone supplementation with regards to the onset of menopause appears to be important.
Non-estrogen conventional and phytochemical treatments for vasomotor symptoms: what needs to be known for practice
  • P. Villaseca
  • Medicine
    Climacteric : the journal of the International Menopause Society
  • 2012
TLDR
There are safe non-hormonal conventional treatments for menopausal VMS, although they are less efficacious than estrogens, and the indication of phytochemicals is for women who make this choice on personal beliefs.
The association between soy nut consumption and decreased menopausal symptoms.
BACKGROUND Epidemiological studies suggest a low incidence of hot flashes in populations that consume dietary soy. The present study examined the effect of soy nuts on hot flashes and menopausal
...
1
2
3
4
5
...