Effects of irreversible and reversible cholinesterase inhibitors on single acetylcholine-activated channels

@article{Zorec2004EffectsOI,
  title={Effects of irreversible and reversible cholinesterase inhibitors on single acetylcholine-activated channels},
  author={R. Zorec and M. Scuka and M. Kordas},
  journal={The Journal of Membrane Biology},
  year={2004},
  volume={125},
  pages={41-48}
}
  • R. Zorec, M. Scuka, M. Kordas
  • Published 2004
  • Chemistry, Medicine
  • The Journal of Membrane Biology
  • SummaryThe use of cholinesterase (CHE) inhibitors provided valuable information about the mechanism(s) of neuromuscular transmission, but questions on side effects at the level of AChactivated channels were raised. Patch-clamp recording was used to study the effects of prostigmine (PST) and methanesulfonyl fluoride (MSF), a reversible and an irreversible cholinesterase inhibitor, respectively, on ACh-activated channels. We found that these drugs diminish the average dwell time of elementary… CONTINUE READING
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