Effects of irreversible and reversible cholinesterase inhibitors on single acetylcholine-activated channels

@article{Zorec2004EffectsOI,
  title={Effects of irreversible and reversible cholinesterase inhibitors on single acetylcholine-activated channels},
  author={R. Zorec and M. Scuka and M. Kordas},
  journal={The Journal of Membrane Biology},
  year={2004},
  volume={125},
  pages={41-48}
}
  • R. Zorec, M. Scuka, M. Kordas
  • Published 2004
  • Chemistry, Medicine
  • The Journal of Membrane Biology
    • SummaryThe use of cholinesterase (CHE) inhibitors provided valuable information about the mechanism(s) of neuromuscular transmission, but questions on side effects at the level of AChactivated channels were raised. Patch-clamp recording was used to study the effects of prostigmine (PST) and methanesulfonyl fluoride (MSF), a reversible and an irreversible cholinesterase inhibitor, respectively, on ACh-activated channels. We found that these drugs diminish the average dwell time of elementary… CONTINUE READING
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    References

    SHOWING 1-10 OF 62 REFERENCES
    The reversible cholinesterase inhibitor physostigmine has channel-blocking and agonist effects on the acetylcholine receptor-ion channel complex.
    • 129
    The effect of anticholinesterase drugs on the ionophoretically-evoked end-plate currents
    • M. Scuka
    • Chemistry, Medicine
    • Pflügers Archiv - European Journal of Physiology
    • 2004
    • 1
    Structure-activity relationship of reversible cholinesterase inhibitors: activation, channel blockade and stereospecificity of the nicotinic acetylcholine receptor-ion channel complex.
    • 39
    The nature of the interactions of pyridostigmine with the nicotinic acetylcholine receptor-ionic channel complex. II. Patch clamp studies.
    • 66
    A study of the irreversible cholinesterase inhibitor, diisopropylfluorophosphate, on time course of end-plate currents in frog sartorius muscle.
    • 90
    The nature of the interactions of pyridostigmine with the nicotinic acetylcholine receptor-ionic channel complex. I. Agonist, desensitizing, and binding properties.
    • 75
    Trifluoperazine reduces inward ionic currents and secretion by separate mechanisms in bovine chromaffin cells.
    • 71
    A comparison of the effect of cholinesterase inhibitors on end-plate current and on cholinesterase activity in frog muscle
    • 59
    Single channel properties of newly synthesized acetylcholine receptors following denervation of mammalian skeletal muscle
    • 44
    • PDF
    A study of curare action with an electrical micro-method
    • J. D. Castillo, B. Katz
    • Chemistry, Medicine
    • Proceedings of the Royal Society of London. Series B - Biological Sciences
    • 1957
    • 177