Effects of iron regulatory protein regulation on iron homeostasis during hypoxia.

@article{Schneider2003EffectsOI,
  title={Effects of iron regulatory protein regulation on iron homeostasis during hypoxia.},
  author={Brian D Schneider and Elizabeth A. Leibold},
  journal={Blood},
  year={2003},
  volume={102 9},
  pages={3404-11}
}
Iron regulatory proteins (IRP1 and IRP2) are RNA-binding proteins that affect the translation and stabilization of specific mRNAs by binding to stem-loop structures known as iron responsive elements (IREs). IREs are found in the 5'-untranslated region (UTR) of ferritin (Ft) and mitochondrial aconitase (m-Aco) mRNAs, and in the 3'-UTR of transferrin receptor (TfR) and divalent metal transporter-1 (DMT1) mRNAs. Our previous studies show that besides iron, IRPs are regulated by hypoxia. Here we… CONTINUE READING

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