Effects of iron overload on chronic metabolic diseases.

  title={Effects of iron overload on chronic metabolic diseases.},
  author={Jos{\'e} Fern{\'a}ndez-Real and Melania Manco},
  journal={The lancet. Diabetes & endocrinology},
  volume={2 6},
Iron can affect the clinical course of several chronic metabolic diseases such as type 2 diabetes, obesity, non-alcoholic fatty liver disease, and atherosclerosis. Iron overload can affect major tissues involved in glucose and lipid metabolism (pancreatic β cells, liver, muscle, and adipose tissue) and organs affected by chronic diabetic complications. Because iron is a potent pro-oxidant, fine-tuned control mechanisms have evolved to regulate entry, recycling, and loss of body iron. These… CONTINUE READING
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