Effects of iron on extracellular and intracellular growth of Penicillium marneffei.

@article{Taramelli2000EffectsOI,
  title={Effects of iron on extracellular and intracellular growth of Penicillium marneffei.},
  author={Donatella Taramelli and Simona Brambilla and Gianluca Sala and Alessandra Bruccoleri and C Tognazioli and L Riviera-Uzielli and Johan R. Boelaert},
  journal={Infection and immunity},
  year={2000},
  volume={68 3},
  pages={1724-6}
}
Killing of intracellular Penicillium marneffei conidia is demonstrated in gamma interferon-lipopolysaccharide-activated human THP1 and mouse J774 cells. Iron overload significantly reduces the antifungal activity of macrophages. Likewise, exogenous iron enhances and iron chelators inhibit the extracellular growth of P. marneffei. These results suggest that… CONTINUE READING