Effects of ionizing radiation on the blood brain barrier permeability to pharmacologically active substances.

@article{Trnovec1990EffectsOI,
  title={Effects of ionizing radiation on the blood brain barrier permeability to pharmacologically active substances.},
  author={Tom{\'a}{\vs} Trnovec and Z. K{\'a}llay and {\vS}tefan Bezek},
  journal={International journal of radiation oncology, biology, physics},
  year={1990},
  volume={19 6},
  pages={1581-7}
}
Ionizing radiation can impair the integrity of the blood brain barrier (BBB). Data on early and late damage after brain irradiation are usually reported separately, yet a gradual transition between these two types has become evident. Signs appearing within 3 weeks after irradiation are considered to be early manifestations. The mechanism of radiation-effected integrity impairment of the BBB is discussed in relation to changes in morphological structures forming the BBB, the endothelium of… CONTINUE READING