Effects of ionizing radiation on biological molecules--mechanisms of damage and emerging methods of detection.

@article{Reisz2014EffectsOI,
  title={Effects of ionizing radiation on biological molecules--mechanisms of damage and emerging methods of detection.},
  author={Julie A Reisz and Nidhi Bansal and Jiang Qian and Weiling Zhao and Cristina M Furdui},
  journal={Antioxidants & redox signaling},
  year={2014},
  volume={21 2},
  pages={260-92}
}
SIGNIFICANCE The detrimental effects of ionizing radiation (IR) involve a highly orchestrated series of events that are amplified by endogenous signaling and culminating in oxidative damage to DNA, lipids, proteins, and many metabolites. Despite the global impact of IR, the molecular mechanisms underlying tissue damage reveal that many biomolecules are chemoselectively modified by IR. RECENT ADVANCES The development of high-throughput "omics" technologies for mapping DNA and protein… CONTINUE READING

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