Effects of ion channel modulators in the influx and efflux of Tc-99m-MIBI

@article{Arbab1999EffectsOI,
  title={Effects of ion channel modulators in the influx and efflux of Tc-99m-MIBI},
  author={A. Arbab and K. Koizumi and K. Toyama and T. Arai and T. Araki},
  journal={Annals of Nuclear Medicine},
  year={1999},
  volume={13},
  pages={27-32}
}
Possible involvement of cell membrane ion transport systems in the uptake and extrusion of Tc-99m-MIBI was investigated by using various buffers with or without Na+ and Ca++, and ion transport inhibitors in a tumor cell line. The ion transport modulators dimethyl amiloride (DMA), verapamil, flunarizine and monensin were used. The uptake of Tc-99m-MIBI was significantly increased in all buffers containing either Na+ or Ca++ alone or none of them. There was significantly increased uptake of Tc… Expand
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