Effects of intravenous metamizole on ongoing and evoked activity of dura-sensitive thalamic neurons in rats.

@article{Sokolov2014EffectsOI,
  title={Effects of intravenous metamizole on ongoing and evoked activity of dura-sensitive thalamic neurons in rats.},
  author={Alexey Y Sokolov and Olga A. Lyubashina and Ivan B. Sivachenko and Sergey Panteleev},
  journal={European journal of pharmacology},
  year={2014},
  volume={731},
  pages={
          58-64
        }
}
Migraine and tension-type headache (TTH) are the most common forms of primary headaches. A general key mechanism underlying development of both the diseases is the trigeminal system activation associated with the ascending nociceptive transmission via the trigemino-thalamo-cortical pathway. The ventroposteromedial (VPM) nucleus is a key thalamic structure, receiving afferent inflow from the craniofacial region; it holds the third-order neurons responsible for conveying sensory information from… CONTINUE READING
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