Effects of intravenous immunoglobulins on mice with experimental epidermolysis bullosa acquisita.

@article{Hirose2015EffectsOI,
  title={Effects of intravenous immunoglobulins on mice with experimental epidermolysis bullosa acquisita.},
  author={Misa Hirose and Benjamin Tiburzy and Norito Ishii and Elena Pipi and Sabina Wende and Ellen Rentz and Falk Nimmerjahn and Detlef Zillikens and Rudolf A Manz and Ralf J Ludwig and Michael Kasperkiewicz},
  journal={The Journal of investigative dermatology},
  year={2015},
  volume={135 3},
  pages={768-775}
}
Although well-designed prospective trials are generally lacking, intravenous immunoglobulins (IVIG) seem an effective adjuvant treatment for autoimmune bullous skin diseases. Here, efficacy of IVIG monotherapy was compared with corticosteroid treatment in mice with immunization-induced experimental epidermolysis bullosa acquisita (EBA), an autoimmune bullous skin disease characterized by autoantibodies against type VII collagen. We found that IVIG significantly ameliorated clinical disease… CONTINUE READING
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